The Laboratory of Translational Neuropsycho药理学 (LTN) designs, leads and coordinates both NIH (NIMH, NIDA and NIAAA) and industry sponsored (investigator-initiated) studies at Dartmouth Hitchcock Medical Center (DHMC), as well as through a network of clinical sites in New Hampshire, 佛蒙特州和全国各地.
The mission of the LTN is to gain a better systems-neuroscience understanding of severe mental illness and 物质使用障碍s in order to develop novel therapeutic interventions and personalize the implementation of existing treatments to improve patients' lives.
The areas of focus of the on-going studies of the group are schizophrenia and co-occurring 物质使用障碍, 还有酗酒, 暴食症, 大麻使用障碍.
- 动物研究: On-going animal research within the LTN is closely linked to the work of the Neuroscience Center at Dartmouth. These translational research studies involve investigation of animal models of schizophrenia and co-occurring substance use to further understand the basis of these disorders, and to test out potential new therapeutic agents and techniques. Other studies probe the neural circuitry of food and drug addiction alone. Among new therapeutic strategies being studied are novel pharmacological approaches and neurosurgical methods to modulate activity of delineated neural circuitry. Methodology includes animal behavior, 药理学, 脑成像, 电生理学, chemogenetics, 局部脑刺激.
- 神经影像学研究: On-going neuroimaging studies (in partnership with the 脑成像实验室) use functional magnetic resonance imaging (fMRI) techniques to elucidate structural and functional deficits in patients with serious psychiatric disorders. One area of focus at present involves the use of fMRI to elucidate brain reward circuitry as a target for therapeutic intervention. A recent study is seeking to assess the effect of cannabis on brain function in people with schizophrenia and co-occurring cannabis use disorder.
- 临床试验: The LTN has a number of on-going clinical trials, most of which are hypothesis testing proof of concept studies. 在这些研究中, therapeutic agents (some of which are also studied within our animal research and neuroimaging programs) can be evaluated in human populations. We also collaborate with sites/groups and affiliated academic institutions, such as the University of Vermont and Northeastern University.
For mor information, contact Elise Bragg at 伊莉斯.m.bragg@hitchcock.org.
我们的成员
- 艾伦,我. 绿色,医学博士，教授及主任
- 玛丽F. 黑发,医学博士, Medical Director and Associate Professor
- Ree Dawson, PhD, Senior Statistician
- Elise Bragg, BS, RLATG, Lab Manager
- 怀尔德·杜塞特，医学博士，助理教授
- Jibran Y. Khokhar, PhD, Collaborating Investigator and Adjunct Assistant Professor
- 安吉拉·米. Henricks, PhD, Post-doctoral Fellow
- 戴安娜J. Wallin, PhD, Post-doctoral Fellow
- 卢卡斯L. 德威尔，理学学士，研究生
- 艾米丽K. Sullivan, BS, Graduate Student
- 帕梅拉·T. 盖格，学士，学习助理
- 萨拉米. Hickey, BS, 研究 Coordinator, Clinical Studies
- 玛丽L. Hynes, RN, BS, MPH, CCRC, Administrative Director, Clinical Studies
- 威廉·凯勒，医学博士，助理教授
- Jeffrey Reed, DO，助理教授
- 罗伯特。米. 罗斯博士，ABPP，副教授
- Susan Whitfield-Gabrieli, PhD, Collaborator and Professor (Northeastern University)
- Rosemarie年代. 沃尔夫，MS，数据经理
- Thomas Zeffiro, MD/PhD, Collaborator
最近的出版物
Visit the PubMed website to see a selection of 出版物 by the Laboratory of Translational Neuropsycho药理学.
目前的资金
- NIH/NIDA: Clozapine for cannabis use disorder in schizophrenia (AIG — 2012-2017)
- NIH/NIDA: Cannabis, schizophrenia and reward: self-medication and agonist treatment? (2013-2020)
- NIH/NIDA: Reward circuit dysfunction, 物质使用障碍, and schizophrenia: a preclinical fMRI-based connectivity study (AIG — 2017-2019)
- NIH/NCATS: SYNERGY: The Dartmouth Clinical and Translational Science Institute (AIG [PI], WD — 2013-2020)
- NIH/NIDA: Applying Novel Technologies and Methods to Inform the Ontology of Self-Regulation (AIG, Co-I - 2015-2020)
- Creare: Self Administered Neuropsychological Assessment Battery (RR, 2015-2017)